Neighborhoods & Streets Alphabet City Share Tweet Share Email Comments Alphabet City is located west of the East Village. Its home to many bistros and shops. Related Items:Neighborhoods in Downtown Manhattan Share Tweet Share Email Share Your Thoughts Share Your Thoughts Leave a Reply Cancel reply Leave a Reply Cancel replyYour email address will not be published. Required fields are marked *Comment * Name * Email * Website Save my name, email, and website in this browser for the next time I comment. Δ Friendly Advice How Manhattan is divided: Downtwon: south of 34th street Midtown: 34th street to 59th street Uptown: north of 59th Street East Side & West Side: Fifth Avenue is the dividing line